06Jun 2018

Impaired melanocortin pathway function in Prader-Willi Syndrome gene-Magel2 deficient mice Merve Oncul, Pelin Dilsiz, Edanur Ates Oz, Tayfun Ates, Iltan Aklan, Esref Celik, Nilufer Sayar Atasoy, Deniz Atasoy Human Molecular Genetics, ddy216, Published: 05 June 2018Article history Received: 10 May 2018 Revision Received: 29 May 2018 Accepted: 30 May 2018 Abstract Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, […]

09Nov 2017

Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting Reza Shahbazi1,7, Ilyas Ozcicek1,2,7, Gurkan Ozturk3 and Kezban Ulubayram1,4,5,6,8 Abstract It is generally known that gold nanoparticles are localised in the cytoplasm and, if synthesised in small sizes or functionalized with specific proteins, they enter the cell nucleus. However, there is no report emphasising the importance of surface functionalization in their […]

22Sep 2017

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumo Benedikt Bosbacha,b,1,2,Ferdinand Rossia,c,1, Yasemin Yozgata,3,Jennifer Looc,Jennifer Q. Zhangc,Georgina Berrozped,Katherine Warpinskid,Imke Ehlersa,4,Darren Veache,Andrew Kwokc,Katia Manovaa,Cristina R. Antonescuf,Ronald P. DeMatteoc,5, Peter Besmera,5 Abstract Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo […]

28Jul 2017

Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice. Caglayan B1, Caglayan AB2, Beker MC2, Yalcin E2, Beker M3, Kelestemur T2, Sertel E2, Ozturk G2, Kilic U4, Sahin F5, Kilic E6. click for article

28Jul 2017

Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT. Beker MC1,2,3, Caglayan B1,2, Yalcin E1,2, Caglayan AB1,2,3, Turkseven S1, Gurel B1,4, Kelestemur T1,2,3, Sertel E1,2, Sahin Z5, Kutlu S3, Kilic U1, Baykal AT4, Kilic E6,7. click for article 28

27Apr 2017

The heart of the matter: cardiac stem cells Esra ÇAĞAVİ1,2,*, Arzuhan KOÇ1,3, Sevilay ŞAHOĞLU GÖKTAŞ1,3 1 Regenerative and Restorative Medical Research Center, İstanbul Medipol University, İstanbul, Turkey 2 Department of Medical Biology, International School of Medicine, İstanbul Medipol University, İstanbul, Turkey 3 Department of Microbiology, Institute of Health Sciences, İstanbul Medipol University, İstanbul, Turkey click […]

17Apr 2017

Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin’sneuroprotective activity after focal cerebral ischemia in mice. Kilic U1, Caglayan AB2, Beker MC2, Gunal MY2, Caglayan B2, Yalcin E2, Kelestemur T2, Gundogdu RZ2, Yulug B3, Yılmaz B4, Kerman BE5, Kilic E6. click for article