Kılıç Lab is interested in the molecular mechanisms involved in ischemia/reperfusion injury. Stroke is one of the leading causes of mortality and the main cause of disability worldwide. Stroke results from the transient or permanent interruption or reduction of the blood supply to a specific part of the brain, due to clot formation or bursting of the blood vessels. Treatment of stroke has a very limited treatment window and not every stroke patient is eligible for this treatment. Therefore, the focus of our research has been to understand the underlying mechanisms of stroke, so as to design new treatment strategies. We use mouse middle cerebral artery occlusion (MCAo) models as well as in vitro cell culture models to study the signaling mechanisms involved in the apoptotic processes resulting from stroke. Our current research mainly consists of investigating the novel pathways associated with cellular survival/death following an ischemic injury.

Our main research topics include:

  • Neurotrophic factors in ischemic injury
  • Solute carriers in brain injury pharmacotherapy
  • Purinergic receptors in cerebral ischemia
  • Nogo-A in aggresome formation
  • Circadian rhythm
  • Oxygen and melatonin treatment in newborn hypoxia-ischemia
  • Diet restrictions in cerebral ischemia

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Research Focus

Team
Prof. Dr. Ertuğrul Kılıç
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