As heart disease is the leading cause of death in the world, our group is interested in understanding cardiac development and disease at the molecular level in order to develop novel therapies for heart diease. Particularly, we are focused on deciphering the roles of stem cells and stem cell-derived cells in cardiac development, disease and […]

Kılıç Lab is interested in the molecular mechanisms involved in ischemia/reperfusion injury. Stroke is one of the leading causes of mortality and the main cause of disability worldwide. Stroke results from the transient or permanent interruption or reduction of the blood supply to a specific part of the brain, due to clot formation or bursting […]

Herbal medicine is the basis of various traditional medicine systems around the world, whereby biologically active compounds naturally contained in plants are used in order to maintain or regain human health. Also a significant number of cancer therapeutics on the market today is based on natural products. Examples are paclitaxel, isolated from the Pacific yew […]

What is the relationship between neuronal activity and behavior? What are the neuronal circuit mechanisms that underlie metabolic disorders? We are interested in neural circuits that regulate feeding behavior and metabolism with a special emphasis of disease models of obesity and eating disorders. Using a variety of cutting edge circuit dissection approaches including optogenetic and […]

The collection of all microorganisms associated with the human body (microbiome) weigh approximately the same as the human brain; substantially outnumber human cells and contribute to orders of magnitude more unique protein coding genes than the number of genes of the human genome. Yet how human microbiome influences human brain in health and diseases and […]

In our lab we mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders.   We are also very interested in research and […]