MALDI Synapt G2-Si High Definition Mass Spectrometry

he MALDI SYNAPT G2-Si MS System enables production optimal results for imaging, chemical materials characterization, proteomics and pharmaceutical applications. The MALDI SYNAPT G2-Si is powered by a solid state laser with a repetition rate of 2.5KHz to maximize the speed of analysis. The laser spot size can be selected for optimising sensitivity and speed of analysis, or for maximizing spatial resolution in Imaging studies. Due to the orthogonal geometry of the Tof analyzer, the source is decoupled from the mass analysis. So, unlike axial MALDI-Tof or Tof/Tof instruments, this ensures that high resolution and accurate mass are achieved in both MS and MS/MS modes across a wide mass range. In addition, SYNAPT is well suited to nonconductive samples such as paraffin embedded tissue sections on glass slides.

High Definition Imaging (HDI) MALDI workflows

MALDI SYNAPT G2-Si HDMS combines T-Wave IMS and QuanTof technology within a streamlined imaging workflow to deliver unparalleled selectivity, clarity and confidence. The HDI MALDI solution provides a unique range of powerful multiplex targeted (IMS/MS/MS) and untargeted (IMS/MSE) workflows from image-centric method set-up to data processing and image generation. Integrated correlation (based on spatial location drift-time related fragment ions) and statistical tools (e.g. PCA, OPLS-DA, S-plots, hierarchical clustering) also combine to deliver more intelligent and confident imaging analysis. The ability to access full UPLC/MS/MS capability on SYNAPT delivers the power of high performance quantitative and discovery analysis from bio-fluids or laser-dissected tissue sections on the same platform.

Application Areas:

  • Proteomics
  • MALDI Imaging